Anti-inflammatory · Morinda Citrifolia Fruit Extract · CAS 90063-52-4

Noni Extract

Anthraquinones and iridoids in noni reduce the plaque index in clinical RCT studies with noni gel and suppress gingival inflammation — confirmed by controlled trials.

QDRO position

We use it

Clinical RCT confirms plaque index and gingivitis reduction; rich phytochemistry with antioxidant and antibacterial profile.

Effective concentration

0.1–3% (extract)

Typical on market: 0.5–2%

What it is

Noni extract is obtained from the fruit, leaves, and roots of Morinda citrifolia — a tropical tree of the Rubiaceae family that has been used for over 2,000 years in Polynesian, Indian (Ayurvedic), and South-East Asian traditional medicine. The fruit is rich in anthraquinones (alizarin, nordamnacanthal), iridoids (deacetylasperuloside), flavonoids, and organic acids. In oral care it is used as an anti-inflammatory and antibacterial agent for gum health.

How it works

Noni's bioactivity is driven by several compound classes:

Anthraquinones — inhibit growth of oral pathogens by disrupting cell-wall synthesis. Antibacterial activity against S. mutans and periodontal pathogens has been demonstrated in vitro.

Iridoids (deacetylasperuloside and scopoletin) — exert anti-inflammatory effects through COX-2 inhibition and reduced IL-1β production in periodontal tissues.

Flavonoids and antioxidants — neutralise reactive oxygen species overproduced during chronic gingival inflammation, reducing collagen destruction in the periodontal ligament.

Efficacy

The clinical RCT by Priya et al. (2012), conducted in patients with gingivitis, showed that noni gel used adjunctively with professional scaling significantly reduced both the Plaque Index (PI) and Gingival Index (GI) compared with the control group at weeks 4 and 8. The trial is small but its design meets RCT standards.

Wang et al. (2002) systematically reviewed the anti-inflammatory, antibacterial, and antioxidant potential of noni — the cumulative evidence base supports its use in gingival formulas.

Safety

Noni has status as a traditional food; noni juice is approved as a Novel Food in the EU. Toxicological studies show good tolerability. Isolated cases of hepatotoxicity have been reported with high-dose oral noni juice consumption — not relevant for oral-care products at 0.5–2% extract concentrations. Allergic reactions are rare.

Role in the QDRO formula

QDRO evaluates noni extract as an ingredient for anti-gingivitis rinses or gum gels within the v.pro line — in combination with aloe vera, pomegranate extract, or propolis. The key consumer communication: "plant-based anti-inflammatory with clinical evidence" — a strong claim for audiences seeking natural yet evidence-backed alternatives to conventional antiseptics.