05 / INGREDIENTS
Ingredients
Active formula or marketing — there is a difference.
95 ingredients
- Abrasive
Activated Charcoal
We avoid itBlack toothpaste went viral. Dentists got worried. Here is what the research actually shows.
- Anti-inflammatory
Allantoin
We use itBleeding gums or persistent irritation? Allantoin accelerates mucosal recovery. Here's how it actually works.
- Anti-inflammatoryN/A
Aloe Vera
We use itAloe vera gel — acemannan, anthraquinones and polysaccharides accelerate epithelial healing, reduce gum inflammation and relieve aphthous ulcers. Clinically comparable to chlorhexidine in gingivitis reduction without side effects.
- Anti-inflammatoryC₁₅H₂₆O
Alpha-Bisabolol
We use itAlpha-bisabolol is a sesquiterpene alcohol from German chamomile that suppresses the inflammatory cascade via NF-κB inhibition and downregulation of COX-2, TNF-α, and IL-6. At 0.1–0.5% it shows clinical efficacy in post-surgical oral care. Here we cover the mechanism and the data.
- Remineralizing
Arginine
We use itA different approach to sensitivity: don't block the nerve, close off the pathway to it. How arginine actually works.
- Anti-inflammatoryC₂₁H₁₈O₁₁
Baicalin
We use itA key TCM flavonoid from Baikal skullcap roots. Reduces gum inflammation without the side effects of synthetic NSAIDs.
- Whitening
Bamboo Charcoal
Not our choiceA highly porous adsorbent, effective against surface pigments and bad breath. But only at the right concentration — most pastes on the market include it for color, not results.
- Gum Care
Beta-Glucan
We use itBeta-glucan from oats and yeast trains oral immune cells to contain inflammation rather than amplify it. We break down the Dectin-1 receptor pathway, clinical evidence from a randomized trial on gingivitis, and why 0.1% is already effective.
- SurfactantC₅H₁₁NO₂
Betaine
We use itNatural zwitterion from sugar beet — softens SLS aggressiveness and protects mucosa from osmotic stress.
- RemineralizingSiO₂·CaO·Na₂O·P₂O₅
Bioglass (NovaMin)
We use itBioglass is a synthetic silicate material that, upon contact with moisture, forms an amorphous layer saturating enamel with calcium and phosphate.
- AbrasiveCaCO₃
Calcium Carbonate
We use itA dual role: a mild, controlled abrasive and the calcium carrier that, together with arginine, physically seals dentinal tubules.
- RemineralizingC₃H₇CaO₆P
Calcium Glycerophosphate
We use itCalcium Glycerophosphate (CaGP) is an organic calcium salt that delivers free Ca²⁺ and phosphate ions directly into dental plaque fluid. Used in Tooth Mousse, clinically validated as a fluoride synergist — especially effective in nano-sized form at 0.25–0.5%.
- Anti-inflammatory
Calendula Extract
We use itCalendula flavonoids and triterpenes accelerate mucosal wound granulation and reduce IL-1β in gingivitis.
- Whitening
Carbamide Peroxide
Not our choiceHow is carbamide peroxide different from hydrogen peroxide? Why dentists rely on it — and what the numbers on at-home kits really mean.
- AntibacterialC₁₀H₁₄O
Carvacrol
We use itPhenolic terpene from oregano — disrupts bacterial and fungal membranes; 3× more potent than fluconazole by MIC against C.albicans.
- Gum Care
Centella Asiatica
We use itCentella asiatica is more than a skincare trend. Three active triterpenoids stimulate collagen, suppress NF-κB inflammation, and show measurable benefit in periodontal clinical trials. Here's the biochemistry.
- Anti-inflammatoryN/A
Chamomile Extract
We use itAzulene and apigenin from chamomile — inhibit COX-1 and COX-2 without systemic effects, reducing gum swelling and redness. Bisabolol additionally accelerates mucosal regeneration.
- Antiseptic
Chlorhexidine
Not our choiceThe gold standard of oral antiseptics. Why you shouldn't use it every day.
- Antisepticeugenol 70–90%
Clove Oil
We use itEugenol (main component) — local anaesthetic and antiseptic. Used in dentistry since Hippocrates. Effective in home products at 0.5–1%; above 2% — risk of mucosal irritation.
- Surfactant
Cocamidopropyl Betaine (CAPB)
We use itCocamidopropyl betaine (CAPB) is an amphoteric surfactant derived from coconut oil, used in toothpaste as a milder alternative to SLS. Clinical studies confirm it causes significantly less mucosal irritation and fewer aphthous ulcers at working concentrations of 1–2%. QDRO uses it as the primary surfactant across the entire product line.
- AntibacterialAg
Colloidal Silver
We avoid itColloidal silver is heavily marketed as a 'natural antibiotic,' but has no confirmed efficacy in oral-care RCTs and carries argyria risk with prolonged use.
- AntibacterialC₁₂H₂₂CuO₁₄
Copper Gluconate
We use itCopper gluconate suppresses oral anaerobes via the Fenton mechanism and reduces plaque formation at 0.025% without the tooth-staining side effects of chlorhexidine.
- Remineralizing
CPP-ACP (Casein Phosphopeptides)
We use itCPP-ACP is a bioactive milk protein complex that anchors calcium and phosphate ions directly on the tooth surface. We break down the mechanism, clinical evidence, and conditions for effectiveness.
- AntibacterialC₂₂H₁₈O₁₁
Epigallocatechin Gallate (EGCG)
We use itThe most active catechin in green tea. Inhibits S. mutans growth, disrupts biofilm, and does not cause resistance.
- AntisepticC₁₀H₁₈O
Eucalyptol (1,8-Cineole)
We use itEucalyptol is the primary active ingredient in Listerine, used in oral care for over 130 years. It disrupts bacterial membranes, suppresses biofilm formation by Streptococcus mutans, and acts synergistically with thymol. Clinical concentration: 0.092%.
- RemineralizingCa₁₀(PO₄)₆F₂
Fluorapatite
We use itFluorapatite is the product of the reaction between enamel hydroxyapatite and fluoride ions; its crystal lattice is significantly more resistant to acid attack than natural enamel.
- anti-sensitivityC₅H₈O₂
Glutaraldehyde
Not our choiceGlutaraldehyde coagulates plasma proteins inside the dentinal tubule to seal it durably. An effective in-office desensitizer — but an allergen and irritant, not for home formulas.
- HumectantC₃H₈O₃
Glycerin
We use itGlycerin is a polyol with a trihydric alcohol group that retains moisture in the paste and on the mucosa, provides a smooth formulation texture, and serves as a solvent for many active ingredients.
- Gum Care(C₁₄H₂₁NO₁₁)ₙ
Hyaluronic Acid
We use itSodium hyaluronate retains water in gum tissue, accelerates healing of mucosal microtraumas and reduces periodontal inflammation — among the most clinically supported ingredients for gum care.
- Abrasive
Hydrated Silica
NeutralHow does toothpaste clean teeth? An abrasive does the work. We explain the RDA index and why not all abrasives are equal.
- WhiteningH₂O₂
Hydrogen Peroxide
Not our choiceThe most studied whitening agent in dentistry. Why concentration is everything — and what separates pharmacy peroxide from professional gel.
- RemineralizingCa₁₀(PO₄)₆(OH)₂
Hydroxyapatite
We use itThe mineral your enamel is made of. Not a metaphor — literally the same material.
- Antibacterial
Japanese Honeysuckle
We use itJapanese honeysuckle flower extract (金银花) is a classic TCM antibacterial ingredient. Active against periodontal pathogens with no risk of resistance.
- AbrasiveAl₂Si₂O₅(OH)₄
Kaolin
We use itWhite clay with an abrasivity index of 40–70. Removes plaque mechanically, adsorbs toxins and neutralizes acids — without damaging enamel.
- probiotic
Lactobacillus reuteri
We use itStrain ATCC 55730 / DSM 17938 produces reuterin, competitively displaces Streptococcus mutans, and demonstrably reduces gum bleeding and periodontal pocket depth in randomized controlled trials.
- probiotic
Lactobacillus salivarius
We use itA native oral probiotic that reduces acid-resistant pathogens without harming commensal flora. Clinical evidence supports its use in caries prevention and gingival inflammation in both children and adults.
- Antibacterial
Lactoferrin
We use itA milk and saliva glycoprotein that chelates Fe³⁺, depriving bacteria of a key growth factor. Active against S.mutans, P.gingivalis, and C.albicans. In toothpastes it works synergistically with lysozyme.
- Antibacterial
Lactoperoxidase
We use itThe enzyme oxidises salivary thiocyanate to hypothiocyanite in the presence of H₂O₂ — the most potent natural antibacterial agent in mucous membranes. The LP+SCN⁻+H₂O₂ system is the foundation of enzyme-based toothpastes and mouthwashes.
- Anti-inflammatoryN/A
Licorice Root
We use itGlycyrrhizin and licochalcones from licorice root — anti-inflammatory and anti-caries effect. Licochalcone A inhibits S.mutans, reduces plaque adhesion, while glycyrrhizin suppresses NF-κB similarly to baicalin.
- Antibacterial
Lysozyme
We use itA natural salivary enzyme that disrupts bacterial cell wall peptidoglycan. In toothpastes it compensates for dry mouth, reduces caries risk, and protects inflamed gums. Especially valuable in xerostomia.
- Remineralizing
Magnesium Chloride
We use itNatural bischofite mineral — magnesium is a component of bone and tooth apatite and regulates osteoblast activity. In mouthwashes it recreates a mineral environment similar to the Dead Sea, supporting enamel remineralisation.
- AntibacterialN/A
Magnolia Bark
We use itHonokiol and magnolol — non-polyphenolic antibacterial agents from magnolia bark. Destroy S.mutans biofilms at 1.56 μg/mL — 20 times more effective than xylitol by MBC.
- AntisepticN/A
Myrrh
We use itCommiphora resin — one of the oldest oral antiseptics. Terpenoids (curcumenes, furano-sesquiterpenes) suppress S.aureus, E.coli and Candida fungi. Used in mouthwashes for stomatitis and periodontitis.
- RemineralizingCa₁₀(PO₄)₆(OH)₂
Nano-hydroxyapatite
We use itNano-hydroxyapatite is a synthetic analogue of tooth enamel mineral that fills micro-defects and restores enamel at the molecular level.
- AntibacterialN/A
Neem
We use itExtract from the neem tree of Ayurvedic medicine — limonoids (nimbin, azadirachtin) inhibit S.mutans adhesion to enamel and disrupt mature biofilms. Traditional neem "tooth" twigs matched a toothbrush in plaque reduction.
- Anti-inflammatory
Noni Extract
We use itAnthraquinones and iridoids in noni reduce the plaque index in clinical RCT studies with noni gel and suppress gingival inflammation — confirmed by controlled trials.
- Gum Care
Oak Bark
We use itOne of the oldest phytotherapeutic ingredients in Russian medicine. Oak bark tannins reduce bleeding, firm gum tissue, and provide antibacterial activity.
- WhiteningC₁₂H₁₃NO₅
PAP (Phthalimidoperoxycaproic Acid)
We use itNext-generation organic peracid — whitens without free H₂O₂, does not irritate soft tissues.
- Flavoringmenthol 30–55%
Peppermint Oil
We use itPeppermint essential oil — source of menthol and menthone, activates TRPM8 receptors, antibacterial against S.mutans.
- WhiteningC₆H₁₈O₂₄P₆
Phytic Acid
We use itFe²⁺/Fe³⁺ chelator from cereal seeds — prevents chromogen oxidation and yellow staining without abrasion.
- Anti-Tartar(NaPO₃)₆
Polyphosphate (Hexametaphosphate)
We use itSodium hexametaphosphate — chelates calcium from pigments and simultaneously blocks tartar crystallisation.
- AntibacterialN/A
Pomegranate Extract
We use itPunicalagins, ellagic acid and anthocyanins of pomegranate — suppress P.gingivalis, F.nucleatum and reduce pathogen adhesion to gum epithelium. Randomised trials in chronic gingivitis showed 52% BOP reduction.
- anti-sensitivityKCl
Potassium Chloride
We use itPotassium chloride reduces tooth sensitivity by depolarising dentinal nerve endings, offering a nitrate-free alternative at 3–5% effective dose.
- anti-sensitivityK₂C₂O₄
Potassium Oxalate
We use itPotassium oxalate precipitates insoluble calcium oxalate crystals that physically plug dentinal tubules. A powerful professional agent with an honest caveat on home use.
- Antibacterial
Propolis
We use itPropolis is the resinous sealant honeybees use to sterilise their hives. In oral care products it suppresses Streptococcus mutans, reduces gingival inflammation and disrupts biofilm formation — with clinical trials to back it up.
- Antibacterial
Sage
We use itClassic phytotherapeutic antiseptic. Effective against S. mutans, P. gingivalis and Candida — without tooth staining or taste disruption.
- Anti-inflammatory
Sea Salt
We use itSea salt is one of dentistry's oldest antiseptics. We break down what the Mg/Ca/K/Br mineral complex actually does to oral mucosa, which concentrations show clinical effect, and where the evidence base stands.
- Remineralizingpeptide (QQRFEWEFEQQ)
Self-Assembling Peptide P11-4
We use itP11-4 is a rationally designed 11-amino-acid peptide that self-assembles into a scaffold inside an early caries lesion and grows fresh hydroxyapatite crystals from the ions in saliva.
- Abrasive
Sodium Bicarbonate
NeutralGenerations of grandmothers can't be wrong. But what baking soda actually does to your teeth — and what it doesn't — is worth knowing precisely.
- Surfactant
Sodium Cocoamphoacetate
We use itSLS triggered mucosal desquamation in 42 of 45 recorded reactions. Amphoteric surfactants: only 3. Sodium cocoamphoacetate — the mechanism, concentrations, and clinical evidence.
- RemineralizingNaF
Sodium Fluoride
We use itThe benchmark anticaries ingredient since the 1960s. How it works and why concentration is everything.
- Anti-CariesNa₂FPO₃
Sodium Monofluorophosphate (MFP)
We use itMFP delivers fluoride through a phosphate-bound molecule, making it fully compatible with calcium-based abrasives where sodium fluoride precipitates. Three-decade clinical record, 0.76% standard concentration.
- Anti-TartarNa₄P₂O₇
Sodium Pyrophosphate
We use itCompetitive crystallisation inhibitor — adsorbs on tartar crystals and blocks their growth.
- Humectant
Sorbitol
NeutralSorbitol is the ingredient nobody notices but everyone uses. What it actually does — and whether it's safe.
- RemineralizingSnF₂
Stannous Fluoride
We use itSnF₂ does everything sodium fluoride does — and then adds an antibacterial layer. Here is what the research actually shows.
- sweetener
Stevia Extract
We use itStevia extract is 200–400× sweeter than sugar, is not fermented by S.mutans, and inhibits α-glucosidase — the enzyme S.mutans needs to build cariogenic biofilm.
- probiotic
Streptococcus salivarius K12
We use itThe BLIS K12 strain produces bacteriocins that suppress S. pyogenes and H. influenzae. Clinical trials show it reduces strep throat recurrence in children by up to 90% and reliably eliminates chronic halitosis.
- anti-sensitivitySr(CH₃COO)₂
Strontium Acetate
We use it8% strontium acetate seals dentinal tubules with strontium-substituted apatite and relieves sensitivity within one minute of application.
- RemineralizingC₇H₈N₄O₂
Theobromine
We use itTheobromine is a natural cacao-bean alkaloid that accelerates the formation of large hydroxyapatite crystals and in several studies surpasses fluoride in the hardness of remineralised enamel.
- AntisepticC₁₀H₁₄O
Thymol
We use itA natural phenol from thyme oil used in oral care since 1879. At 0.064% it disrupts bacterial membranes, suppresses S. mutans biofilm, and shows antifungal activity against Candida albicans — without causing tooth staining.
- Gum Care
Tienchi Ginseng
We use itOne of the most valuable ingredients in traditional Chinese medicine. Stops gum bleeding and reduces inflammation in chronic gingivitis.
- WhiteningTiO₂
Titanium Dioxide
We avoid itTitanium dioxide makes paste look white but does not whiten teeth. The nano form was banned in the EU in 2022 due to genotoxicity on inhalation; oral safety studies are ongoing.
- Gum CareC₃₁H₅₂O₃
Tocopherol (Vitamin E)
We use itVitamin E is a fat-soluble antioxidant that neutralises free radicals in gingival tissue and supports regeneration of inflamed mucosa. Clinical trials confirm moderate improvements in periodontal parameters. We break down the biochemistry and effective concentrations.
- AntibacterialC₁₂H₇Cl₃O₂
Triclosan
We avoid itTriclosan was added to toothpastes for decades as an antibacterial agent with solid clinical evidence behind it. The EU banned it in cosmetics in 2016 following data on endocrine disruption. Here's the full picture: mechanism, efficacy, and why we avoid it.
- Gum CareC₆H₈O₆
Vitamin C (Ascorbic Acid)
We use itVitamin C is not just an immune booster. In the oral cavity it acts as a collagen synthesis cofactor and potent antioxidant. Here are the mechanisms and the real effective concentrations.
- RemineralizingC₂₇H₄₄O
Vitamin D3
We use itCholecalciferol regulates calcium and phosphorus absorption, controls dentine mineralisation and supports the periodontal immune response — but only through systemic intake, not in a toothpaste.
- RemineralizingC₄₆H₆₄O₂
Vitamin K2 (MK-7)
We use itMenaquinone-7 activates carboxylase proteins that direct calcium into bones and dentine rather than arteries — an irreplaceable systemic cofactor of remineralisation.
- excipient
Xanthan Gum
We use itXanthan gum is a thixotropic biopolymer that keeps paste firm in the tube and spreads effortlessly during brushing, preserving the stability of every active ingredient.
- Anti-CariesC₅H₁₂O₅
Xylitol
We use itA five-carbon sugar alcohol with a unique mechanism: S. mutans captures the molecule but cannot break it down and is depleted. Proven caries reduction of 30–60%.
- Anti-TartarC₁₂H₁₀O₁₄Zn₃
Zinc Citrate
We use itZn²⁺ ions inhibit tartar crystallization, neutralize VSCs (odor molecules) and suppress bacterial enzymatic activity. The standard in professional toothpastes.
- Antibacterial
Zinc Gluconate
We use itThe most bioavailable zinc salt for oral use — inhibits enzymes that synthesise volatile sulphur compounds (VSC) and suppresses plaque formation. Outperforms zinc chloride at equivalent doses.
- AntibacterialC₁₀H₈N₂O₂S₂Zn
Zinc Pyrithione
We use itZinc pyrithione disrupts ion transport in pathogens, suppressing S.mutans, P.gingivalis, and C.albicans at 0.5% without tooth staining.
- Whitening
Бромелайн
NeutralBromelain is a proteolytic enzyme from pineapple used in toothpaste as a natural alternative to peroxide whiteners. It dissolves the protein matrix of dental pellicle to remove surface stains. We examine the mechanism and why clinical evidence remains limited.
- RemineralizingCa₃(PO₄)₂
Кальций-фосфат
We use itCalcium and phosphate are the building blocks of enamel. The question is how to deliver them where they're needed. A look at ACP, TCP, and NovaMin technology.
- Gum CareC₅₉H₉₀O₄
Коэнзим Q10 (Убихинон)
We use itInflamed gum tissue is deficient in Coenzyme Q10 — a fact documented since 1971. Ubiquinone replenishes the antioxidant barrier in periodontal membranes, curbs lipid peroxidation, and has randomized clinical data to support its use as a gum-care adjunct.
- Surfactant
Лаурилсульфат натрия
Not our choiceSodium lauryl sulfate creates foam. But foam is not cleaning. We break down the mechanism, the risks, and what works instead.
- Antibacterial
Масло чайного дерева
We use itTea tree oil contains terpinen-4-ol — a compound that disrupts bacterial cell membranes. Clinical trials demonstrate efficacy against gingivitis comparable to chlorhexidine at 0.2–0.5% concentration, without tooth staining or taste alteration.
- Flavoring
Ментол
We use itThat cool sensation after brushing is menthol. But it does more than create a pleasant smell. We break down the antibacterial effect and the TRPM8 mechanism.
- anti-sensitivityKNO₃
Нитрат калия
We use itCold drinks trigger a sharp sting. Potassium nitrate doesn't seal the tooth — it works at the nerve itself.
- AntibacterialZnO
Оксид цинка
We use itZnO is a mineral antibacterial agent with a dual mechanism: it disrupts bacterial cell membranes and neutralizes volatile sulfur compounds — the primary cause of bad breath. Effective at concentrations from 0.5%.
- Whitening
Папаин
NeutralPapain is a proteolytic enzyme from papaya latex that degrades the acquired enamel pellicle, removing extrinsic stains. Clinical evidence exists but is limited in scale; formula instability remains the key challenge.
- WhiteningNa₂CO₃·1.5H₂O₂
Перкарбонат натрия
Not our choiceSodium percarbonate is a stable solid source of hydrogen peroxide widely used in whitening films and gels. It releases active oxygen on contact with saliva, delivering clinically measurable whitening — but long-term safety data for use in daily toothpaste remains limited.
- anti-sensitivitySrCl₂
Хлорид стронция
Not our choiceStrontium chloride is one of the first scientifically studied desensitizers — in use since the 1950s. It works by physically occluding dentinal tubules with Sr²⁺ ions. Clinical evidence exists, but it is more modest than that for potassium nitrate or nano-hydroxyapatite.
- Antiseptic
Цетилпиридиния хлорид
We use itCPC delivers real antibacterial action without the side-effect profile of chlorhexidine. No staining. No microbiome disruption. Just daily protection.
- Anti-CariesC₄H₁₀O₄
Эритрит
We use itA four-carbon polyol found naturally in fruits and fermented foods. A 3-year RCT on 485 children demonstrated superior plaque reduction and S. mutans suppression compared to xylitol and sorbitol. Bacteria cannot ferment erythritol — no acid, no demineralization.