Ingredients

95 ingredients

• Abrasive

  Activated Charcoal

  We avoid it

  Black toothpaste went viral. Dentists got worried. Here is what the research actually shows.

• Anti-inflammatory

  Allantoin

  We use it

  Bleeding gums or persistent irritation? Allantoin accelerates mucosal recovery. Here's how it actually works.

• Anti-inflammatory

  N/A

  Aloe Vera

  We use it

  Aloe vera gel — acemannan, anthraquinones and polysaccharides accelerate epithelial healing, reduce gum inflammation and relieve aphthous ulcers. Clinically comparable to chlorhexidine in gingivitis reduction without side effects.

• Anti-inflammatory

  C₁₅H₂₆O

  Alpha-Bisabolol

  We use it

  Alpha-bisabolol is a sesquiterpene alcohol from German chamomile that suppresses the inflammatory cascade via NF-κB inhibition and downregulation of COX-2, TNF-α, and IL-6. At 0.1–0.5% it shows clinical efficacy in post-surgical oral care. Here we cover the mechanism and the data.

• Remineralizing

  Arginine

  We use it

  A different approach to sensitivity: don't block the nerve, close off the pathway to it. How arginine actually works.

• Anti-inflammatory

  C₂₁H₁₈O₁₁

  Baicalin

  We use it

  A key TCM flavonoid from Baikal skullcap roots. Reduces gum inflammation without the side effects of synthetic NSAIDs.

• Whitening

  Bamboo Charcoal

  Not our choice

  A highly porous adsorbent, effective against surface pigments and bad breath. But only at the right concentration — most pastes on the market include it for color, not results.

• Gum Care

  Beta-Glucan

  We use it

  Beta-glucan from oats and yeast trains oral immune cells to contain inflammation rather than amplify it. We break down the Dectin-1 receptor pathway, clinical evidence from a randomized trial on gingivitis, and why 0.1% is already effective.

• Surfactant

  C₅H₁₁NO₂

  Betaine

  We use it

  Natural zwitterion from sugar beet — softens SLS aggressiveness and protects mucosa from osmotic stress.

• Remineralizing

  SiO₂·CaO·Na₂O·P₂O₅

  Bioglass (NovaMin)

  We use it

  Bioglass is a synthetic silicate material that, upon contact with moisture, forms an amorphous layer saturating enamel with calcium and phosphate.

• Abrasive

  CaCO₃

  Calcium Carbonate

  We use it

  A dual role: a mild, controlled abrasive and the calcium carrier that, together with arginine, physically seals dentinal tubules.

• Remineralizing

  C₃H₇CaO₆P

  Calcium Glycerophosphate

  We use it

  Calcium Glycerophosphate (CaGP) is an organic calcium salt that delivers free Ca²⁺ and phosphate ions directly into dental plaque fluid. Used in Tooth Mousse, clinically validated as a fluoride synergist — especially effective in nano-sized form at 0.25–0.5%.

• Anti-inflammatory

  Calendula Extract

  We use it

  Calendula flavonoids and triterpenes accelerate mucosal wound granulation and reduce IL-1β in gingivitis.

• Whitening

  Carbamide Peroxide

  Not our choice

  How is carbamide peroxide different from hydrogen peroxide? Why dentists rely on it — and what the numbers on at-home kits really mean.

• Antibacterial

  C₁₀H₁₄O

  Carvacrol

  We use it

  Phenolic terpene from oregano — disrupts bacterial and fungal membranes; 3× more potent than fluconazole by MIC against C.albicans.

• Gum Care

  Centella Asiatica

  We use it

  Centella asiatica is more than a skincare trend. Three active triterpenoids stimulate collagen, suppress NF-κB inflammation, and show measurable benefit in periodontal clinical trials. Here's the biochemistry.

• Anti-inflammatory

  N/A

  Chamomile Extract

  We use it

  Azulene and apigenin from chamomile — inhibit COX-1 and COX-2 without systemic effects, reducing gum swelling and redness. Bisabolol additionally accelerates mucosal regeneration.

• Antiseptic

  Chlorhexidine

  Not our choice

  The gold standard of oral antiseptics. Why you shouldn't use it every day.

• Antiseptic

  eugenol 70–90%

  Clove Oil

  We use it

  Eugenol (main component) — local anaesthetic and antiseptic. Used in dentistry since Hippocrates. Effective in home products at 0.5–1%; above 2% — risk of mucosal irritation.

• Surfactant

  Cocamidopropyl Betaine (CAPB)

  We use it

  Cocamidopropyl betaine (CAPB) is an amphoteric surfactant derived from coconut oil, used in toothpaste as a milder alternative to SLS. Clinical studies confirm it causes significantly less mucosal irritation and fewer aphthous ulcers at working concentrations of 1–2%. QDRO uses it as the primary surfactant across the entire product line.

• Antibacterial

  Ag

  Colloidal Silver

  We avoid it

  Colloidal silver is heavily marketed as a 'natural antibiotic,' but has no confirmed efficacy in oral-care RCTs and carries argyria risk with prolonged use.

• Antibacterial

  C₁₂H₂₂CuO₁₄

  Copper Gluconate

  We use it

  Copper gluconate suppresses oral anaerobes via the Fenton mechanism and reduces plaque formation at 0.025% without the tooth-staining side effects of chlorhexidine.

• Remineralizing

  CPP-ACP (Casein Phosphopeptides)

  We use it

  CPP-ACP is a bioactive milk protein complex that anchors calcium and phosphate ions directly on the tooth surface. We break down the mechanism, clinical evidence, and conditions for effectiveness.

• Antibacterial

  C₂₂H₁₈O₁₁

  Epigallocatechin Gallate (EGCG)

  We use it

  The most active catechin in green tea. Inhibits S. mutans growth, disrupts biofilm, and does not cause resistance.

• Antiseptic

  C₁₀H₁₈O

  Eucalyptol (1,8-Cineole)

  We use it

  Eucalyptol is the primary active ingredient in Listerine, used in oral care for over 130 years. It disrupts bacterial membranes, suppresses biofilm formation by Streptococcus mutans, and acts synergistically with thymol. Clinical concentration: 0.092%.

• Remineralizing

  Ca₁₀(PO₄)₆F₂

  Fluorapatite

  We use it

  Fluorapatite is the product of the reaction between enamel hydroxyapatite and fluoride ions; its crystal lattice is significantly more resistant to acid attack than natural enamel.

• anti-sensitivity

  C₅H₈O₂

  Glutaraldehyde

  Not our choice

  Glutaraldehyde coagulates plasma proteins inside the dentinal tubule to seal it durably. An effective in-office desensitizer — but an allergen and irritant, not for home formulas.

• Humectant

  C₃H₈O₃

  Glycerin

  We use it

  Glycerin is a polyol with a trihydric alcohol group that retains moisture in the paste and on the mucosa, provides a smooth formulation texture, and serves as a solvent for many active ingredients.

• Gum Care

  (C₁₄H₂₁NO₁₁)ₙ

  Hyaluronic Acid

  We use it

  Sodium hyaluronate retains water in gum tissue, accelerates healing of mucosal microtraumas and reduces periodontal inflammation — among the most clinically supported ingredients for gum care.

• Abrasive

  Hydrated Silica

  Neutral

  How does toothpaste clean teeth? An abrasive does the work. We explain the RDA index and why not all abrasives are equal.

• Whitening

  H₂O₂

  Hydrogen Peroxide

  Not our choice

  The most studied whitening agent in dentistry. Why concentration is everything — and what separates pharmacy peroxide from professional gel.

• Remineralizing

  Ca₁₀(PO₄)₆(OH)₂

  Hydroxyapatite

  We use it

  The mineral your enamel is made of. Not a metaphor — literally the same material.

• Antibacterial

  Japanese Honeysuckle

  We use it

  Japanese honeysuckle flower extract (金银花) is a classic TCM antibacterial ingredient. Active against periodontal pathogens with no risk of resistance.

• Abrasive

  Al₂Si₂O₅(OH)₄

  Kaolin

  We use it

  White clay with an abrasivity index of 40–70. Removes plaque mechanically, adsorbs toxins and neutralizes acids — without damaging enamel.

• probiotic

  Lactobacillus reuteri

  We use it

  Strain ATCC 55730 / DSM 17938 produces reuterin, competitively displaces Streptococcus mutans, and demonstrably reduces gum bleeding and periodontal pocket depth in randomized controlled trials.

• probiotic

  Lactobacillus salivarius

  We use it

  A native oral probiotic that reduces acid-resistant pathogens without harming commensal flora. Clinical evidence supports its use in caries prevention and gingival inflammation in both children and adults.

• Antibacterial

  Lactoferrin

  We use it

  A milk and saliva glycoprotein that chelates Fe³⁺, depriving bacteria of a key growth factor. Active against S.mutans, P.gingivalis, and C.albicans. In toothpastes it works synergistically with lysozyme.

• Antibacterial

  Lactoperoxidase

  We use it

  The enzyme oxidises salivary thiocyanate to hypothiocyanite in the presence of H₂O₂ — the most potent natural antibacterial agent in mucous membranes. The LP+SCN⁻+H₂O₂ system is the foundation of enzyme-based toothpastes and mouthwashes.

• Anti-inflammatory

  N/A

  Licorice Root

  We use it

  Glycyrrhizin and licochalcones from licorice root — anti-inflammatory and anti-caries effect. Licochalcone A inhibits S.mutans, reduces plaque adhesion, while glycyrrhizin suppresses NF-κB similarly to baicalin.

• Antibacterial

  Lysozyme

  We use it

  A natural salivary enzyme that disrupts bacterial cell wall peptidoglycan. In toothpastes it compensates for dry mouth, reduces caries risk, and protects inflamed gums. Especially valuable in xerostomia.

• Remineralizing

  Magnesium Chloride

  We use it

  Natural bischofite mineral — magnesium is a component of bone and tooth apatite and regulates osteoblast activity. In mouthwashes it recreates a mineral environment similar to the Dead Sea, supporting enamel remineralisation.

• Antibacterial

  N/A

  Magnolia Bark

  We use it

  Honokiol and magnolol — non-polyphenolic antibacterial agents from magnolia bark. Destroy S.mutans biofilms at 1.56 μg/mL — 20 times more effective than xylitol by MBC.

• Antiseptic

  N/A

  Myrrh

  We use it

  Commiphora resin — one of the oldest oral antiseptics. Terpenoids (curcumenes, furano-sesquiterpenes) suppress S.aureus, E.coli and Candida fungi. Used in mouthwashes for stomatitis and periodontitis.

• Remineralizing

  Ca₁₀(PO₄)₆(OH)₂

  Nano-hydroxyapatite

  We use it

  Nano-hydroxyapatite is a synthetic analogue of tooth enamel mineral that fills micro-defects and restores enamel at the molecular level.

• Antibacterial

  N/A

  Neem

  We use it

  Extract from the neem tree of Ayurvedic medicine — limonoids (nimbin, azadirachtin) inhibit S.mutans adhesion to enamel and disrupt mature biofilms. Traditional neem "tooth" twigs matched a toothbrush in plaque reduction.

• Anti-inflammatory

  Noni Extract

  We use it

  Anthraquinones and iridoids in noni reduce the plaque index in clinical RCT studies with noni gel and suppress gingival inflammation — confirmed by controlled trials.

• Gum Care

  Oak Bark

  We use it

  One of the oldest phytotherapeutic ingredients in Russian medicine. Oak bark tannins reduce bleeding, firm gum tissue, and provide antibacterial activity.

• Whitening

  C₁₂H₁₃NO₅

  PAP (Phthalimidoperoxycaproic Acid)

  We use it

  Next-generation organic peracid — whitens without free H₂O₂, does not irritate soft tissues.

• Flavoring

  menthol 30–55%

  Peppermint Oil

  We use it

  Peppermint essential oil — source of menthol and menthone, activates TRPM8 receptors, antibacterial against S.mutans.

• Whitening

  C₆H₁₈O₂₄P₆

  Phytic Acid

  We use it

  Fe²⁺/Fe³⁺ chelator from cereal seeds — prevents chromogen oxidation and yellow staining without abrasion.

• Anti-Tartar

  (NaPO₃)₆

  Polyphosphate (Hexametaphosphate)

  We use it

  Sodium hexametaphosphate — chelates calcium from pigments and simultaneously blocks tartar crystallisation.

• Antibacterial

  N/A

  Pomegranate Extract

  We use it

  Punicalagins, ellagic acid and anthocyanins of pomegranate — suppress P.gingivalis, F.nucleatum and reduce pathogen adhesion to gum epithelium. Randomised trials in chronic gingivitis showed 52% BOP reduction.

• anti-sensitivity

  KCl

  Potassium Chloride

  We use it

  Potassium chloride reduces tooth sensitivity by depolarising dentinal nerve endings, offering a nitrate-free alternative at 3–5% effective dose.

• anti-sensitivity

  K₂C₂O₄

  Potassium Oxalate

  We use it

  Potassium oxalate precipitates insoluble calcium oxalate crystals that physically plug dentinal tubules. A powerful professional agent with an honest caveat on home use.

• Antibacterial

  Propolis

  We use it

  Propolis is the resinous sealant honeybees use to sterilise their hives. In oral care products it suppresses Streptococcus mutans, reduces gingival inflammation and disrupts biofilm formation — with clinical trials to back it up.

• Antibacterial

  Sage

  We use it

  Classic phytotherapeutic antiseptic. Effective against S. mutans, P. gingivalis and Candida — without tooth staining or taste disruption.

• Anti-inflammatory

  Sea Salt

  We use it

  Sea salt is one of dentistry's oldest antiseptics. We break down what the Mg/Ca/K/Br mineral complex actually does to oral mucosa, which concentrations show clinical effect, and where the evidence base stands.

• Remineralizing

  peptide (QQRFEWEFEQQ)

  Self-Assembling Peptide P11-4

  We use it

  P11-4 is a rationally designed 11-amino-acid peptide that self-assembles into a scaffold inside an early caries lesion and grows fresh hydroxyapatite crystals from the ions in saliva.

• Abrasive

  Sodium Bicarbonate

  Neutral

  Generations of grandmothers can't be wrong. But what baking soda actually does to your teeth — and what it doesn't — is worth knowing precisely.

• Surfactant

  Sodium Cocoamphoacetate

  We use it

  SLS triggered mucosal desquamation in 42 of 45 recorded reactions. Amphoteric surfactants: only 3. Sodium cocoamphoacetate — the mechanism, concentrations, and clinical evidence.

• Remineralizing

  NaF

  Sodium Fluoride

  We use it

  The benchmark anticaries ingredient since the 1960s. How it works and why concentration is everything.

• Anti-Caries

  Na₂FPO₃

  Sodium Monofluorophosphate (MFP)

  We use it

  MFP delivers fluoride through a phosphate-bound molecule, making it fully compatible with calcium-based abrasives where sodium fluoride precipitates. Three-decade clinical record, 0.76% standard concentration.

• Anti-Tartar

  Na₄P₂O₇

  Sodium Pyrophosphate

  We use it

  Competitive crystallisation inhibitor — adsorbs on tartar crystals and blocks their growth.

• Humectant

  Sorbitol

  Neutral

  Sorbitol is the ingredient nobody notices but everyone uses. What it actually does — and whether it's safe.

• Remineralizing

  SnF₂

  Stannous Fluoride

  We use it

  SnF₂ does everything sodium fluoride does — and then adds an antibacterial layer. Here is what the research actually shows.

• sweetener

  Stevia Extract

  We use it

  Stevia extract is 200–400× sweeter than sugar, is not fermented by S.mutans, and inhibits α-glucosidase — the enzyme S.mutans needs to build cariogenic biofilm.

• probiotic

  Streptococcus salivarius K12

  We use it

  The BLIS K12 strain produces bacteriocins that suppress S. pyogenes and H. influenzae. Clinical trials show it reduces strep throat recurrence in children by up to 90% and reliably eliminates chronic halitosis.

• anti-sensitivity

  Sr(CH₃COO)₂

  Strontium Acetate

  We use it

  8% strontium acetate seals dentinal tubules with strontium-substituted apatite and relieves sensitivity within one minute of application.

• Remineralizing

  C₇H₈N₄O₂

  Theobromine

  We use it

  Theobromine is a natural cacao-bean alkaloid that accelerates the formation of large hydroxyapatite crystals and in several studies surpasses fluoride in the hardness of remineralised enamel.

• Antiseptic

  C₁₀H₁₄O

  Thymol

  We use it

  A natural phenol from thyme oil used in oral care since 1879. At 0.064% it disrupts bacterial membranes, suppresses S. mutans biofilm, and shows antifungal activity against Candida albicans — without causing tooth staining.

• Gum Care

  Tienchi Ginseng

  We use it

  One of the most valuable ingredients in traditional Chinese medicine. Stops gum bleeding and reduces inflammation in chronic gingivitis.

• Whitening

  TiO₂

  Titanium Dioxide

  We avoid it

  Titanium dioxide makes paste look white but does not whiten teeth. The nano form was banned in the EU in 2022 due to genotoxicity on inhalation; oral safety studies are ongoing.

• Gum Care

  C₃₁H₅₂O₃

  Tocopherol (Vitamin E)

  We use it

  Vitamin E is a fat-soluble antioxidant that neutralises free radicals in gingival tissue and supports regeneration of inflamed mucosa. Clinical trials confirm moderate improvements in periodontal parameters. We break down the biochemistry and effective concentrations.

• Antibacterial

  C₁₂H₇Cl₃O₂

  Triclosan

  We avoid it

  Triclosan was added to toothpastes for decades as an antibacterial agent with solid clinical evidence behind it. The EU banned it in cosmetics in 2016 following data on endocrine disruption. Here's the full picture: mechanism, efficacy, and why we avoid it.

• Gum Care

  C₆H₈O₆

  Vitamin C (Ascorbic Acid)

  We use it

  Vitamin C is not just an immune booster. In the oral cavity it acts as a collagen synthesis cofactor and potent antioxidant. Here are the mechanisms and the real effective concentrations.

• Remineralizing

  C₂₇H₄₄O

  Vitamin D3

  We use it

  Cholecalciferol regulates calcium and phosphorus absorption, controls dentine mineralisation and supports the periodontal immune response — but only through systemic intake, not in a toothpaste.

• Remineralizing

  C₄₆H₆₄O₂

  Vitamin K2 (MK-7)

  We use it

  Menaquinone-7 activates carboxylase proteins that direct calcium into bones and dentine rather than arteries — an irreplaceable systemic cofactor of remineralisation.

• excipient

  Xanthan Gum

  We use it

  Xanthan gum is a thixotropic biopolymer that keeps paste firm in the tube and spreads effortlessly during brushing, preserving the stability of every active ingredient.

• Anti-Caries

  C₅H₁₂O₅

  Xylitol

  We use it

  A five-carbon sugar alcohol with a unique mechanism: S. mutans captures the molecule but cannot break it down and is depleted. Proven caries reduction of 30–60%.

• Anti-Tartar

  C₁₂H₁₀O₁₄Zn₃

  Zinc Citrate

  We use it

  Zn²⁺ ions inhibit tartar crystallization, neutralize VSCs (odor molecules) and suppress bacterial enzymatic activity. The standard in professional toothpastes.

• Antibacterial

  Zinc Gluconate

  We use it

  The most bioavailable zinc salt for oral use — inhibits enzymes that synthesise volatile sulphur compounds (VSC) and suppresses plaque formation. Outperforms zinc chloride at equivalent doses.

• Antibacterial

  C₁₀H₈N₂O₂S₂Zn

  Zinc Pyrithione

  We use it

  Zinc pyrithione disrupts ion transport in pathogens, suppressing S.mutans, P.gingivalis, and C.albicans at 0.5% without tooth staining.

• Whitening

  Бромелайн

  Neutral

  Bromelain is a proteolytic enzyme from pineapple used in toothpaste as a natural alternative to peroxide whiteners. It dissolves the protein matrix of dental pellicle to remove surface stains. We examine the mechanism and why clinical evidence remains limited.

• Remineralizing

  Ca₃(PO₄)₂

  Кальций-фосфат

  We use it

  Calcium and phosphate are the building blocks of enamel. The question is how to deliver them where they're needed. A look at ACP, TCP, and NovaMin technology.

• Gum Care

  C₅₉H₉₀O₄

  Коэнзим Q10 (Убихинон)

  We use it

  Inflamed gum tissue is deficient in Coenzyme Q10 — a fact documented since 1971. Ubiquinone replenishes the antioxidant barrier in periodontal membranes, curbs lipid peroxidation, and has randomized clinical data to support its use as a gum-care adjunct.

• Surfactant

  Лаурилсульфат натрия

  Not our choice

  Sodium lauryl sulfate creates foam. But foam is not cleaning. We break down the mechanism, the risks, and what works instead.

• Antibacterial

  Масло чайного дерева

  We use it

  Tea tree oil contains terpinen-4-ol — a compound that disrupts bacterial cell membranes. Clinical trials demonstrate efficacy against gingivitis comparable to chlorhexidine at 0.2–0.5% concentration, without tooth staining or taste alteration.

• Flavoring

  Ментол

  We use it

  That cool sensation after brushing is menthol. But it does more than create a pleasant smell. We break down the antibacterial effect and the TRPM8 mechanism.

• anti-sensitivity

  KNO₃

  Нитрат калия

  We use it

  Cold drinks trigger a sharp sting. Potassium nitrate doesn't seal the tooth — it works at the nerve itself.

• Antibacterial

  ZnO

  Оксид цинка

  We use it

  ZnO is a mineral antibacterial agent with a dual mechanism: it disrupts bacterial cell membranes and neutralizes volatile sulfur compounds — the primary cause of bad breath. Effective at concentrations from 0.5%.

• Whitening

  Папаин

  Neutral

  Papain is a proteolytic enzyme from papaya latex that degrades the acquired enamel pellicle, removing extrinsic stains. Clinical evidence exists but is limited in scale; formula instability remains the key challenge.

• Whitening

  Na₂CO₃·1.5H₂O₂

  Перкарбонат натрия

  Not our choice

  Sodium percarbonate is a stable solid source of hydrogen peroxide widely used in whitening films and gels. It releases active oxygen on contact with saliva, delivering clinically measurable whitening — but long-term safety data for use in daily toothpaste remains limited.

• anti-sensitivity

  SrCl₂

  Хлорид стронция

  Not our choice

  Strontium chloride is one of the first scientifically studied desensitizers — in use since the 1950s. It works by physically occluding dentinal tubules with Sr²⁺ ions. Clinical evidence exists, but it is more modest than that for potassium nitrate or nano-hydroxyapatite.

• Antiseptic

  Цетилпиридиния хлорид

  We use it

  CPC delivers real antibacterial action without the side-effect profile of chlorhexidine. No staining. No microbiome disruption. Just daily protection.

• Anti-Caries

  C₄H₁₀O₄

  Эритрит

  We use it

  A four-carbon polyol found naturally in fruits and fermented foods. A 3-year RCT on 485 children demonstrated superior plaque reduction and S. mutans suppression compared to xylitol and sorbitol. Bacteria cannot ferment erythritol — no acid, no demineralization.